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Comprehensive TIP-ChIP Solutions
TIP-ChIP™ Tagmented, Indexed and Pooled ChIP-Seq: Assay Kit and Service for Multi-Sample ChIP in a Single Reaction
Tagmented, Indexed and Pooled ChIP-Seq (TIP-ChIP) is a breakthrough method to achieve consistent ChIP-Seq data sets for histone modifications and transcription factors with rapid and simple processing.
TIP-ChIP starts with the unbiased opening and tagmentation of chromatin, inserting sequencing adapters across the genome in a 96-well plate format. The samples are then pooled into a single tube, where sonication efficiently releases the tagmented protein/DNA complexes. Next, the samples are transferred to a single tube for the immunoprecipitation reaction, seamlessly continuing the ChIP protocol to deliver high-quality, reliable results.
This innovative workflow eliminates sample-to-sample technical variability, reduces effects and simplifies the ChIP-Seq assay, enabling simultaneous processing of up to 96 samples with only 300,000 to 1,000,000 cells required per sample, and an integrated library preparation method.
End-to-end service for high-throughput, low input multi-sample ChIP-Seq.
Maximize throughput and minimize variability with multi-sample ChIP in a single reaction.
Learn More From Our TIP-ChIP Experts
[Blog] The Latest ChIP Tip – How to Measure Single-cell Chromatin States with itChIP-Seq
March 26, 2025
Researchers headed by Aibin He at Peking University recently reported itChIP-Seq - indexing and tagmentation-based ChIP-Seq - as a simple, cost-effective, and widely applicable means of measuring chromatin states in low-input cell and single-cell samples. This exciting technique became the basis for Active Motif’s TIP-ChIP method – making the approach easily available for your workflow. Learn how it works!
[Webinar] TIP-ChIP: Tagmented, Indexed, and Pooled ChIP - High-throughput results, low input samples
In this webinar, Active Motif Scientist Sarah Traynor discusses using a new technique TIP-ChIP (Tagmented, Indexed, and Pooled ChIP), which is paired with the PIXUL multi-sample sonicator instrument to generate high-throughput, multi-sample results from low input samples.
[Poster] TIP-ChIP: Tagmented, Indexed, and Pooled ChIP-Seq to Generate High-Throughput, Multi-Sample Results for Low Input Samples
Access this poster which was presented by Active Motif Research Scientist Sarah Traynor at American Society of Human Genetics (ASHG), 2025, describing a new ChIP method, designed to reduce cell number requirements, increase throughput, and minimize sample-to-sample variability compared to traditional ChIP. TIP-ChIP was applied to multiple stimulus-response models, capturing dynamic shifts in H3K27ac, H3K4me3, RNA Pol II Ser2, and NF-κB to uncover coordinated enhancer, promoter, and transcriptional activity during inflammation.
