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DNA Methylation Alterations in Neurodegenerative Diseases (Paula Desplats)

Episode 101

June 1, 2023

In this episode of the Epigenetics Podcast, we caught up with Paula Desplats from the University of California, San Diego to talk about her work on DNA methylation alterations in neurodegenerative diseases.

The Desplats lab focuses on decoding the role of epigenetic mechanisms, in particular DNA methylation, on the onset and progression of neurodegenerative diseases like Parkinson’s and Alzheimer’s. One of the goals of the Desplats team is to develop a biomarker panel, based on quantification of DNA methylation of selected genes, that may be able to discriminate Parkison's Disease patients from healthy subjects in a simple blood test. More recently, the team also focused on the role of the circadian rhythm on neurodegenerative diseases and exploring whether interventions can help in managing the disease.


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