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Active Motif eBooks
Stay up-to-date with the latest publications from our epigenetics experts.
In this eBook, we are inspired by both the original landmark publication “The Hallmarks of Aging” by López-Otín et al., Cell, 2013 and their 2023 update (López-Otín et al., Cell, 2023), which now includes processes ranging from epigenetic alterations to genomic instability, stem cell exhaustion to inflammation, changes in nuclear architecture and other key features of aging at the cellular level. With Active Motif’s expertise in epigenetics, our focus here will be on the aging hallmark of epigenetic changes, with an emphasis on key biological targets and pathways as presented during a series of seminars during Chromatin-Con 2023: Epigenetics of Aging. Several hallmarks are discussed, as well as methods for their analysis featured during this event.Download Epigenetics of Aging eBook
CUT&Tag 是一项非常有价值的技术，可用于研究组蛋白修饰和一些转录因子的基因组定位，可揭示蛋白质与 DNA 之间的相互作用或识别目标蛋白质的 DNA 结合位点。
这本免费电子书概述了 CUT&Tag、以及它与其它基于 ChIP 的protocol的方法的比较，还有开始在研究中使用 CUT&Tag 所需了解的一切。
The chromatin immunoprecipitation (ChIP) assay changed the way researchers can study protein-DNA interactions and epigenetic modifications of histones. However, ChIP assays are difficult. ChIP protocols have many steps that each require optimization, making it hard to consistently generate high-quality data you can trust.
This free eBook makes it easy to become a ChIP assay expert by covering the main steps in the ChIP workflow and giving pointers on how to achieve the best results.
There is increasing evidence that many neurodevelopmental, neurodegenerative, and psychiatric disorders are caused at least in part by aberrant epigenetic modifications.
As a result, neuroscience researchers are now beginning to investigate the epigenetic mechanisms responsible for regulation of gene expression in neuronal cells and how this impacts normal brain function. This free eBook will help you get started with epigenetics and guide you towards the best approaches to take to answer your specific research questions.
MicroRNAs (miRNAs) have been associated with essentially all aspects of cancer, including diagnosis, staging, progression, prognosis, and response to treatment. Their misexpression can contribute to tumor initiation, growth, and metastasis, making miRNAs attractive therapeutic targets and potentially useful diagnostic tools.
The rapid advancements in microRNA (miRNA) research requires new experimental tools to enable scientists to accurately and efficiently study the role of miRNAs in cancer and other diseases. This MicroRNAs in Cancer eBook summarizes the current miRNA research approaches and outlines how to design and execute an miRNA target screen.