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Non-coding RNAs (ncRNAs) and Cancer

The discovery of non-coding RNAs (ncRNAs) and their role in gene regulation represents a significant advance in cancer research. These ncRNAs interact with DNA, RNA or protein molecules and/or some combination therof, acting as an essential regulator in chromatin organization, transcriptional, and post-transcriptional regulation. The functional relevance of ncRNAs is particularly evident for microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), which have been associated with all stages of cancer including diagnosis, staging, progression, prognosis, and response to treatment. Their misexpression confers upon a cancer cell the capacity for tumor initiation, growth, and metastasis, making ncRNAs attractive therapeutic targets and potentially useful diagnostic tools.

Active Motif has developed an extensive selection of tools and services to study the various aspects of ncRNA mediated gene regulation.
Purify nuclear and cytoplasmic specific RNA populations
RNA Subcellular Isolation Kit Our RNA Subcellular Isolation Kit provides an efficient method to isolate nuclear, cytoplasmic, or total RNA without cross-contamination or the use of phenolic compounds. This method also improves the accuracy of gene expression profiling and can help to localize long non-coding RNAs (lncRNAs) to their site of action, which can provide important insights into their functional role. More >
Isolate mRNA targets of miRNAs
antibodies The Active Motif miRNA Target IP Kit is designed to identify the physical interactions of a specific miRNA with endogenous mRNA transcripts. The immunoprecipitation of miRNA/mRNA complexes enables validation of the specific binding targets of your miRNA of interest. More >