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Single-Cell Multiome Services

Single-Cell Multiome Services for the 10x Genomics and the BD Biosciences Rhapsody Platforms

Active Motif offers two Single-Cell Multiome services: 10x Genomics platform and the BD Biosciences Rhapsody platform. Choosing the right platform depends on your study goals, scale, and experimental design. Both approaches enable simultaneous profiling of gene expression (RNA) and chromatin accessibility (ATAC) from the same cells, but they differ in workflow, multiplexing capabilities, cost efficiency, and ideal use cases. The comparison below highlights the key features of each system to help you determine the best fit for your research.

Category 10x Genomics Multiome BD Biosciences Rhapsody Multiome (4-sample tagging)
Core approach Droplet-based (GEMs) Microwell-based capture
Multiome integration RNA + ATAC from same droplet RNA + ATAC from same cell (separate libraries)
Transcriptome Whole transcriptome Whole transcriptome
ATAC coverage Genome-wide Genome-wide
Barcoding Cell barcode + UMI (bead in droplet) Cell barcode + UMI (bead in microwell)
Multiplexing method None Built-in sample tagging (antibody-oligo)
Multiplet detection Limited Built-in via instrument imaging
Reads per cell (RNA) ~25k ~25k
Reads per cell (ATAC) ~25k ~25k
Cost per sample Higher Lower (shared run via multiplexing)
Bioinformatics Cell Ranger ARC + Secondary analysis BD Single Cell pipeline + Secondary Analysis
Single-Cell 10x Genomics Multiome Service​
Single-Cell 10x Genomics Multiome Service​

10x Genomics Certified Service Provider of Single-Cell Multiome to measure genome-wide gene expression & open chromatin.

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Single-Cell Multiome-Rhapsody Service
Single-Cell BD Biosciences Rhapsody Multiome

Multiplexed single-cell RNA and ATAC analysis for cost-efficient sample processing.

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