Active Motif,
Tools to analyze nuclear function,
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表观遗传 & 染色质

激活剂 / 抑制剂

表观遗传研究的小分子物质

Active Motif has a collection of small-molecule epigenetic modulators (activators and inhibitors) that target changes to DNA methylation and chromatin remodeling proteins, such as histones. These include targets to DNA Methyltransferases (DNMTs), Histone Acetyltransferases (HATs), Histone Deacetylases (HDACs), Histone Methyltransferases (HMTs), Histone Demethylases (HDMs) and a distinct set of chromatin readers, bromodomains. As epigenetic dysregulation is implicated in many diseases, these modulators represent important tools for researchers in their assay development and drug discovery initiatives.

A list of the available activators and inhibitors for epigenetic research is shown below. Please click on the small molecule name to view complete product information.

 
Name Appl. Format Cat No. Price  
2'-Deoxy-5-fluorocytidine DNMT Inhibitor 250 mg 14108 ¥5,735 Buy Now
50 mg 14109 ¥1,472.50 Buy Now
5-Aza-2’-deoxycytidine (Decitabine) DNMT Inhibitor 50 mg 14100 ¥5,967.50 Buy Now
10 mg 14101 ¥1,627.50 Buy Now
5-Azacytidine DNMT Inhibitor 250 mg 14102 ¥1,317.50 Buy Now
50 mg 14103 ¥387.50 Buy Now
6-Thioguanine DNMT Inhibitor 1 g 14126 ¥1,937.50 Buy Now
100 mg 14127 ¥542.50 Buy Now
AK-7 SIRT2 Inhibitor 25 mg 14054 ¥4,030 Buy Now
5 mg 14055 ¥1,007.50 Buy Now
Apicidin HDAC Inhibitor 5 mg 14040 ¥4,107.50 Buy Now
1 mg 14041 ¥1,162.50 Buy Now
Arecoline hydrobromide ACAT1 Inhibitor 1 g 14132 ¥1,317.50 Buy Now
250 mg 14133 ¥542.50 Buy Now
AS-8351 KDM5B Inhibitor 25 mg 14112 ¥3,100 Buy Now
5 mg 14113 ¥775 Buy Now
BIX-01294 G9a/GLP Inhibitor 25 mg 14072 ¥6,975 Buy Now
5 mg 14073 ¥1,550 Buy Now
BML-210 HDAC Inhibitor 25 mg 14048 ¥3,720 Buy Now
5 mg 14049 ¥1,007.50 Buy Now
BML-278 SIRT1 Activator 25 mg 14024 ¥4,417.50 Buy Now
5 mg 14025 ¥1,162.50 Buy Now
C646 p300/CBP Inhibitor 25 mg 14052 ¥3,487.50 Buy Now
5 mg 14053 ¥930 Buy Now
Chaetocin SU(VAR)3-9 Methyltransferase Inhibitor 200 µg 14051 ¥1,240 Buy Now
CI-994 HDAC Inhibitor 25 mg 14092 ¥4,495 Buy Now
5 mg 14093 ¥1,317.50 Buy Now
CPTH2 Gcn5P Inhibitor 25 mg 14094 ¥4,495 Buy Now
5 mg 14095 ¥1,317.50 Buy Now
CTPB p300 Activator 25 mg 14064 ¥3,100 Buy Now
5 mg 14065 ¥852.50 Buy Now
CUDC-101 HDAC and Receptor Tyrosine Kinase Inhibitor 25 mg 14060 ¥7,750 Buy Now
5 mg 14061 ¥1,937.50 Buy Now
Daminozide KDM2/KDM7 Inhibitor 250 mg 14058 ¥2,170 Buy Now
50 mg 14059 ¥697.50 Buy Now
DMOG PHD/JMJD2A Inhibitor 50 mg 14062 ¥2,790 Buy Now
10 mg 14063 ¥775 Buy Now
Embelin PCAF Inhibitor 50 mg 14118 ¥3,797.50 Buy Now
10 mg 14119 ¥852.50 Buy Now
EX-527 SIRT1 Inhibitor 25 mg 14028 ¥2,480 Buy Now
5 mg 14029 ¥697.50 Buy Now
FK-866 HCl Nampt Inhibitor 25 mg 14030 ¥4,650 Buy Now
5 mg 14031 ¥1,162.50 Buy Now
Garcinol p300/pCAF Inhbitor 50 mg 14076 ¥5,270 Buy Now
10 mg 14077 ¥1,240 Buy Now
GSK-J1 (cell impermeable) JMJD3/UTX Inhibitor 25 mg 14068 ¥4,960 Buy Now
5 mg 14069 ¥1,240 Buy Now
GSK-J4 (cell permeable) JMJD3/UTX Inhibitor 25 mg 14070 ¥4,960 Buy Now
5 mg 14071 ¥1,240 Buy Now
HPA (Hexyl-4-pentynoic acid) HDAC Inhibitor 50 mg 14034 ¥1,705 Buy Now
10 mg 14035 ¥697.50 Buy Now
IOX1 JMJD Family Inhibitor 25 mg 14056 ¥4,495 Buy Now
5 mg 14057 ¥1,162.50 Buy Now
JIB-04 JMJD Family Inhibitor 25 mg 14134 ¥3,487.50 Buy Now
5 mg 14135 ¥1,007.50 Buy Now
JQ1 (+/-) BET Bromodomain Inhibitor 25 mg 14066 ¥6,200 Buy Now
5 mg 14067 ¥1,937.50 Buy Now
Mithramycin A DNMT1 Inhibitor 5 mg 14128 ¥2,480 Buy Now
1 mg 14129 ¥620 Buy Now
ML-324 JMJD2 Inhibitor 25 mg 14078 ¥5,270 Buy Now
5 mg 14079 ¥1,317.50 Buy Now
Mocetinostat HDAC Inhibitor 25 mg 14136 ¥4,650 Buy Now
5 mg 14137 ¥1,240 Buy Now
MS-275 HDAC Inhibitor 25 mg 14042 ¥3,100 Buy Now
5 mg 14043 ¥930 Buy Now
NSC-663284 SETD8 Inhibitor 25 mg 14122 ¥5,812.50 Buy Now
5 mg 14123 ¥1,472.50 Buy Now
Panobinostat Class I and II HDAC Inhibitor 25 mg 14044 ¥4,107.50 Buy Now
5 mg 14045 ¥1,162.50 Buy Now
PBIT JARID1 Inhibitor 25 mg 14110 ¥3,642.50 Buy Now
5 mg 14111 ¥1,007.50 Buy Now
Piceatannol SIRT1 Activator 25 mg 14036 ¥3,487.50 Buy Now
5 mg 14037 ¥930 Buy Now
Resveratrol SIRT1 Activator 500 mg 14022 ¥3,487.50 Buy Now
100 mg 14023 ¥852.50 Buy Now
RG108 Non-nucleoside DNMT Inhibitor 25 mg 14104 ¥3,410 Buy Now
5 mg 14105 ¥852.50 Buy Now
Romidepsin HDAC Inhibitor 5 mg 14082 ¥3,100 Buy Now
1 mg 14083 ¥930 Buy Now
RVX-208 BET Bromodomain Antagonist 25 mg 14090 ¥4,727.50 Buy Now
5 mg 14091 ¥1,395 Buy Now
Salermide SIRT Inhibitor 25 mg 14124 ¥2,480 Buy Now
5 mg 14125 ¥620 Buy Now
SGC707 PRMT3 Inhibitor 25 mg 14130 ¥4,727.50 Buy Now
5 mg 14131 ¥1,240 Buy Now
Sinefungin Methyltransferase Inhibitor 5 mg 14088 ¥3,952.50 Buy Now
1 mg 14089 ¥1,162.50 Buy Now
SirtAct SIRT1 Activator 25 mg 14080 ¥5,890 Buy Now
5 mg 14081 ¥2,325 Buy Now
Sirtinol SIRT Inhibitor 25 mg 14074 ¥5,425 Buy Now
5 mg 14075 ¥1,550 Buy Now
Sodium phenylbutyrate HDAC Inhibitor 5 g 14032 ¥1,395 Buy Now
1 g 14033 ¥465 Buy Now
Splitomicin Sir2p (yeast Sirt1 homolog) Inhibitor 25 mg 14086 ¥3,410 Buy Now
5 mg 14087 ¥775 Buy Now
TC-E-5003 PRMT1 Inhibitor 50 mg 14099 ¥1,085 Buy Now
TM-2-51 HDAC8 Activator 50 mg 14096 ¥3,177.50 Buy Now
10 mg 14097 ¥930 Buy Now
Tranylcypromine hemisulfate LSD1/BHC110 Inhibitor 250 mg 14046 ¥2,325 Buy Now
50 mg 14047 ¥697.50 Buy Now
Triacetyl resveratrol SIRT Activator 250 mg 14116 ¥3,255 Buy Now
50 mg 14117 ¥1,007.50 Buy Now
Trichostatin A HDAC Inhibitor 5 mg 14038 ¥4,960 Buy Now
1 mg 14039 ¥1,317.50 Buy Now
Tubastatin A hydrochloride HDAC6 Inhibitor 25 mg 14084 ¥6,122.50 Buy Now
5 mg 14085 ¥1,705 Buy Now
UNC1999 EZH1 & EZH2 Inhibitor 25 mg 14114 ¥3,720 Buy Now
5 mg 14115 ¥930 Buy Now
UNC-2170 Methyl-lysine Binding Protein Inhibitor 25 mg 14120 ¥3,487.50 Buy Now
5 mg 14121 ¥1,162.50 Buy Now
Valproic Acid, sodium salt HDAC Inhibitor 5 g 14021 ¥542.50 Buy Now
Vorinostat (SAHA) HDAC Inhibitor 50 mg 14026 ¥1,937.50 Buy Now
10 mg 14027 ¥775 Buy Now
Zebularine DNMT Inhibitor 25 mg 14106 ¥3,875 Buy Now
5 mg 14107 ¥1,085 Buy Now