MicroRNAs in Cancer eBook
Guide to Studying miRNAs and Performing Screens
- Introduction to miRNAs and cancer
- Experimental approaches for analyzing miRNAs
- Performing high-throughput miRNA screens
- Case study involving a genome-wide screen to identify new targets of miR-122
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Roles of miRNAs in Cancer Biology
MicroRNAs (miRNAs) are an abundant class of small non-coding RNAs that are important regulators of gene expression. miRNAs play a role in numerous biological processes such as cellular signaling, cell differentiation, development, and apoptosis. Mutations and improper regulation of miRNAs have been linked to a variety of physiological disorders such as cancer and heart disease. The emergence of miRNAs has been one of the defining developments in cancer biology over the past decade.