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Histone methylation is a reversible reaction that occurs on lysine or arginine residues of histone tails. Histone methyltransferases (HMTs) catalyze the transfer of a methyl group, while histone demethylases (HDMs) perform the antagonistic action of removing the methyl group. Lysine residues can be mono-, di- or tri-methylated and arginine residues can undergo asymmetric or symmetric dimethylation. Histone methylation plays an important role in transcriptional regulation.
Active Motif offers several small molecules to study the effect of changes in HMT and HDM activity.
| Name | Appl. | Format | Cat No. | Price | |
|---|---|---|---|---|---|
| AS-8351 | KDM5B Inhibitor | 25 mg | 14112 | ¥2,670 | Buy |
| 5 mg | 14113 | ¥780 | Buy | ||
| BIX-01294 | G9a/GLP Inhibitor | 25 mg | 14072 | ¥6,180 | Buy |
| 5 mg | 14073 | ¥1,500 | Buy | ||
| Chaetocin | SU(VAR)3-9 Methyltransferase Inhibitor | 200 µg | 14051 | ¥1,170 | Buy |
| Daminozide | KDM2/KDM7 Inhibitor | 250 mg | 14058 | ¥2,080 | Buy |
| 50 mg | 14059 | ¥650 | Buy | ||
| DMOG | PHD/JMJD2A Inhibitor | 50 mg | 14062 | ¥2,670 | Buy |
| 10 mg | 14063 | ¥780 | Buy | ||
| GSK-J1 (cell impermeable) | JMJD3/UTX Inhibitor | 25 mg | 14068 | ¥4,290 | Buy |
| 5 mg | 14069 | ¥1,170 | Buy | ||
| GSK-J4 (cell permeable) | JMJD3/UTX Inhibitor | 25 mg | 14070 | ¥4,290 | Buy |
| 5 mg | 14071 | ¥1,170 | Buy | ||
| IOX1 | JMJD Family Inhibitor | 25 mg | 14056 | ¥4,030 | Buy |
| 5 mg | 14057 | ¥1,040 | Buy | ||
| JIB-04 | JMJD Family Inhibitor | 25 mg | 14134 | ¥3,060 | Buy |
| 5 mg | 14135 | ¥910 | Buy | ||
| ML-324 | JMJD2 Inhibitor | 25 mg | 14078 | ¥4,810 | Buy |
| 5 mg | 14079 | ¥1,170 | Buy |
