TC-E-5003
Aliases: N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide) |
Catalog No: 14099 | Format: 50 mg | ¥1,110 | Buy |
Application: Histone Methylation (HMT & HDM) |
Chemical Properties
MW = 401.3
C16H14Cl2N2O4S
CAS 17328-16-4
>98% (TLC); NMR (Conforms)
Description
Selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.5 µM) . Displays no activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF-7 breast cancer cells and LNCaP prostate cancer cells. Blocks androgen-induced gene expression in LNCaP cells (ref1).
Contents
White powder. May be dissolved in DMSO (50 mg/ml); DMF (50 mg/ml); Ethanol (nil).
Storage Conditions
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.
References
1. EM Bissinger et al. Bioorg. Med. Chem. Lett. 2011, 19:3717